BEYOND SILVER DIAMINE FLUORIDE: EMERGING ZINC-BASED STRATEGIES FOR CARIES ARREST WITHOUT TOOTH DISCOLORATION
DOI:
https://doi.org/10.56238/revgeov17n4-056Keywords:
Dental Caries, Zinc Compounds, Caries Arrest, Remineralization, Antimicrobial Agents, Silver Diamine Fluoride Alternatives, Biofilm Inhibition, Minimally Invasive DentistryAbstract
Objective: To explore emerging zinc-based strategies as alternatives to silver diamine fluoride (SDF) for caries arrest, with a focus on maintaining efficacy while avoiding tooth discoloration.
Methodology: A narrative review of the literature was performed using databases such as PubMed, Scopus, and Web of Science. Studies investigating zinc-based compounds and their antimicrobial, remineralizing, and anti-cariogenic properties were included. Data were qualitatively analyzed to compare these approaches with conventional SDF therapy.
Results: Zinc-based formulations have shown promising antimicrobial activity against cariogenic bacteria, particularly Streptococcus mutans, and demonstrate the ability to inhibit biofilm formation. Additionally, these compounds contribute to enamel remineralization and dentin stabilization. Unlike SDF, zinc-based agents do not cause undesirable black staining, which is a major limitation of SDF in aesthetic zones. However, the current evidence is largely derived from in vitro and preliminary clinical studies, with limited long-term clinical validation.
Conclusion: Zinc-based strategies represent a promising alternative for caries management, particularly in patients where aesthetics are a concern. While early findings are encouraging, further well-designed clinical trials are necessary to establish their long-term effectiveness and safety. Their integration into minimally invasive dentistry could expand treatment options beyond traditional SDF.
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References
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